Adjuvant 5-fluorouracil plus levamisole in colon cancer: the plot thickens?
نویسندگان
چکیده
منابع مشابه
Phase I Trial of Sulindac plus 5-Fluorouracil and Levamisole: Potential Adjuvant Therapy for Colon Carcinoma
I N T R O D U C T I O N Adjuvant chemotherapy with 5-FU 2 and levamisole was shown to significantly improve survival rates in patients with resected lymph node-positive (stage III) colon carcinomas (1). Attempts to improve on these results are being actively pursued. Epidemiological (2-7), clinical (8-12), and laboratory (13-19) studies indicate that NSAIDs, including sulindac, may reduce color...
متن کاملPhase I trial of sulindac plus 5-fluorouracil and levamisole: potential adjuvant therapy for colon carcinoma.
Epidemiological studies indicate that nonsteroidal anti-inflammatory agents may reduce colorectal cancer incidence and mortality. Moreover, sulindac has been shown to attenuate the growth and progression of colonic neoplasms in an experimental model of colon carcinoma and in patients with familial adenomatous polyposis. To determine whether sulindac (300 mg/day) would increase toxicity associat...
متن کاملPhase I Trial of Sulindac plus 5-Fluorouracil and Levamisole: Potential Adjuvant Therapy for Colon Carcinoma
I N T R O D U C T I O N Adjuvant chemotherapy with 5-FU 2 and levamisole was shown to significantly improve survival rates in patients with resected lymph node-positive (stage III) colon carcinomas (1). Attempts to improve on these results are being actively pursued. Epidemiological (2-7), clinical (8-12), and laboratory (13-19) studies indicate that NSAIDs, including sulindac, may reduce color...
متن کاملEffects of 5-fluorouracil adjuvant treatment of colon cancer.
Since the late 1980s and early 1990s, 5-fluorouracil-based chemotherapy has been the standard adjuvant treatment for Stage III colon cancer. After the initial introduction of 5-fluorouracil in standard treatment protocols, several changes have been made based on results of randomized studies on various treatment regimens, including new cytotoxic agents. In Stage II patients, the role of adjuvan...
متن کاملA Randomized Trial Comparing Cisplatin Plus 5-fluorouracil With or Without Levamisole in Operable Gastric Cancer
OBJECTIVES To determine the effectiveness and toxicity when levamisole was added to the adjuvant combination chemotherapy in patients with operable gastric cancer. METHODS After en bloc resection of gastric cancer without gross or microscopic evidence of residual disease from April 1991 to December 1992, 100 patients were randomized to 6 months of 5-fluorouracil 1,000 mg/m2/day administered a...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1994
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1994.193